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Signal peptides in biosimilar development: Small sequences, big impact

With over 200 biosimilars approved globally (1) and many top-selling biologics losing exclusivity in the next five years, the demand for cost-efficient, large-scale production of recombinant antibody therapeutics is growing.

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Signal peptides in biosimilar development: Small sequences, big impact

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PRESS RELEASE

June 11, 2025

Avenue Biosciences Selected for 2025 BioTools Innovator Accelerator Program

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Avenue Biosciences Selected for 2025 BioTools Innovator Accelerator Program

May 20, 2025

Veli-Pekka Jaakola joins Avenue Biosciences as Chief Technology Officer

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Veli-Pekka Jaakola joins Avenue Biosciences as Chief Technology Officer

October 22, 2024

Avenue Biosciences Raises $2.5M Seed to Scale AI-Enhanced Protein Engineering

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Avenue Biosciences Raises $2.5M Seed to Scale AI-Enhanced Protein Engineering

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Blog post
Published on 
October 16, 2024
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All

Signal peptides – a significantly underutilized element in protein engineering

Despite existing in hundreds of thousands and expressing significant diversity, signal peptides have largely remained unexplored in commercial protein engineering. This is a missed opportunity as almost all therapeutic proteins and mRNA therapies contain a signal peptide that can be engineered for optimized production and functionality.

Signal peptides – a significantly underutilized element in protein engineering
Events
Published on 
October 7, 2024
By 
Avenue Biosciences Team
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Avenue Biosciences attending PEGS

Meet us at PEGS Europe 2024

PEGS Europe, a biologics technology conference will be held in Barcelona, on November 5-7. Join our talk on November 6 by CEO Tero-Pekka Alastalo on optimizing protein expression with signal peptides.

Meet us at PEGS Europe 2024