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Understanding signal peptides: Small expression elements and their therapeutic implications

This blog sheds light on the significant role of signal peptides in protein synthesis and therapy development.

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Understanding signal peptides: Small expression elements and their therapeutic implications

News

PRESS RELEASE

May 20, 2025

Veli-Pekka Jaakola joins Avenue Biosciences as Chief Technology Officer

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Veli-Pekka Jaakola joins Avenue Biosciences as Chief Technology Officer

October 22, 2024

Avenue Biosciences Raises $2.5M Seed to Scale AI-Enhanced Protein Engineering

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Avenue Biosciences Raises $2.5M Seed to Scale AI-Enhanced Protein Engineering

October 7, 2024

Avenue Biosciences Welcomes Industry Experts to Advisory Board for Market Insights and Focused Growth

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Avenue Biosciences Welcomes Industry Experts to Advisory Board for Market Insights and Focused Growth

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Blog post
Published on 
May 12, 2025
By 
All

Understanding signal peptides: Small expression elements and their therapeutic implications

This blog sheds light on the significant role of signal peptides in protein synthesis and therapy development.

Understanding signal peptides: Small expression elements and their therapeutic implications
Blog post
Published on 
April 8, 2025
By 
All
Abstract of AI designed proteins

Using signal peptides to enhance expression of de novo-designed proteins

In this blog, we examine how signal peptide engineering can address challenges in the expression of de novo-designed proteins.

Using signal peptides to enhance expression of de novo-designed proteins
Blog post
Published on 
December 18, 2024
By 
All
abstract futuristic elements

Leveraging signal peptides for smarter mRNA design

Advances in high throughput signal peptide analysis and computational models are creating new possibilities for smarter mRNA design. 

Leveraging signal peptides for smarter mRNA design
Blog post
Published on 
October 16, 2024
By 
All

Signal peptides – a significantly underutilized element in protein engineering

Despite existing in hundreds of thousands and expressing significant diversity, signal peptides have largely remained unexplored in commercial protein engineering. This is a missed opportunity as almost all therapeutic proteins and mRNA therapies contain a signal peptide that can be engineered for optimized production and functionality.

Signal peptides – a significantly underutilized element in protein engineering
Events
Published on 
October 7, 2024
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Avenue Biosciences Team
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Avenue Biosciences attending PEGS

Meet us at PEGS Europe 2024

PEGS Europe, a biologics technology conference will be held in Barcelona, on November 5-7. Join our talk on November 6 by CEO Tero-Pekka Alastalo on optimizing protein expression with signal peptides.

Meet us at PEGS Europe 2024